Pharmacogenetic Testing (PGx)

Lincoln Diagnostic Lab offers an extensive pharmacogenetic test menu to help the clinician in identifying appropriate treatment and to monitor efficacy and toxicity by evaluating the genetic differences in metabolic pathways for each individual.

Gene Panels Available:

AccuCARDIAC Panel
Genes tested: CYP2C19, CYP2D6, CYP2C9, CYP3A4, CYP3A5, SLCO1B1, APOE, VKORC1, LPA, ITGB3

AccuPSYCH Panel
Genes tested: CYP2C19, CYP2D6, CYP2C9, CYP3A4, CYP3A5, CYP1A2, ANKK1/DRD2, COMT, HTR2A, HTR2C, UGT2B15

AccuPAIN Panel
Genes tested: CYP2C19, CYP2D6, CYP2C9, CYP3A4, CYP3A5, CYP1A2, CYP2B6, OPRM1

AccuCOMPREHENSIVE Panel
Genes tested: CYP2C19, CYP2D6, CYP2C9, CYP3A4, CYP3A5, CYP1A2, CYP2B6, SLCO1B1, APOE, VKORC1, ANKK1/DRD2, OPRM1, COMT, HTR2B, LPA, ITGB3, UGT2B15

Other gene(s) tested:
CYP2C9/VKORC1
CYP2D6
CYP2C19

What are pharmacogenetic tests and why use them for patient testing?
Pharmacogenetics is a field of research that seeks to understand genetic variability that leads to individual responses to medications. The long-term goal of pharmacogenetics is to help healthcare professionals (HCPs) select the drugs and dosages best suited for each person. By analyzing genes that produce specific drug targets, for example, a HCP may be able to adjust medication dosage for precision, optimizing efficacy and safety. The decision about which drug to prescribe may also be influenced by existing health contraindications or maintenance medications.

Pharmacogenetic testing is important in therapeutic decision-making. The Food and Drug Administration has begun including pharmacogenetic information on the labels of more than 150 medications, which can helps HCPS tailor their prescriptions to individual patients. Dosages and timing of therapies are usually based upon the anticipated metabolism and clearance rates of the average person, which is where pharmacogenetic testing comes in. Pharmacogenetic testing provides HCPs with the opportunity to personalize medication to best suit the individual. Being able to test patients for their response to a particular therapy helps provide efficacy and safety insight prior to starting the patient on a new therapeutic regime.

Lincoln Diagnostic Lab offers pharmacogenetic tests that can provide data to aid clinicians in the therapeutic decision making process.

References:

1. Pharmacogenetic tests. American Association for Clinical Chemistry. Website: https://labtestsonline.org/understanding/analytes/pharmacogenetic-tests/. Updated: April 3, 2014. Accessed: April 3, 2016.
2. Pharmacogenetics fact sheet. National Institute of General Medical Sciences. Website: http://www.nigms.nih.gov/education/Pages/factsheet-pharmacogenomics.aspx. Updated: October 1, 2015. Accessed: April 3, 2016.
3. Gervasini G et al. Pharmacogenetic testing and therapeutic drug monitoring are complementary tools for optimal individualization of drug therapy. Eur J Clin Pharmacol. 2010;66:755-774.

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